Tokyo, Oct. 2 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059241) titled 'A Multicenter Prospective Registry of Systemic Therapy for Unresectable Hepatocellular Carcinoma with Linked Multi-omics Biobanking and Translational Validation' on Oct. 1.

Study Type: Observational

Primary Sponsor: Institute - The University of Osaka

Condition: Condition - Hepatocellular Carcinoma Classification by malignancy - Malignancy Genomic information - YES

Objective: Narrative objectives1 - To elucidate predictors of therapeutic efficacy for each pharmacologic treatment of hepatocellular carcinoma and to identify clinically useful blood-based and histopathologic biomarkers. We will prospectively register all patients with HCC who are indicated for systemic therapy at Osaka University and collaborating institutions nationwide in a centralized database, collect clinical, hematologic, and histopathologic data obtained before and after treatment initiation, and analyze their associations with antitumor response and clinical outcomes. Basic objectives2 - Safety,Efficacy

Eligibility: Age-lower limit - 20 years-old

Gender - Male and Female Key inclusion criteria - 1. Patients aged over 20 years 2. Life expectancy of >12 weeks 3. Hepatocellular carcinoma diagnosed by histology, cytology or by imaging such as dynamic contrast enhanced CT or MRI 4. Not amenable to locoregional therapy and eligible for systemic pharmacotherapy 5. ECOG Performance Status 0 or 1 6. No contraindications to the planned agents per the approved package insertm, prescribing information Key exclusion criteria - 1. Patients from whom informed consent cannot be obtained 2. Patients deemed unsuitable for the study by the principal investigator or a subinvestigator Target Size - 1000

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 09 Month 30 Day Date of IRB - 2025 Year 09 Month 12 Day Anticipated trial start date - 2025 Year 10 Month 01 Day Last follow-up date - 2032 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067756

Disclaimer: Curated by HT Syndication.