Tokyo, Sept. 24 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000063011) titled 'Multicenter retrospective study of carbon-ion re-irradiation for recurrent or secondary lung cancer after radiotherapy' on Sept. 24.

Study Type: Observational

Primary Sponsor: Institute - Osaka Heavy Ion Center

Condition: Condition - Primary lung cancer (Locoregional recurrence, pulmonary metastasis, or secondary lung cancer after radiotherapy) Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - To retrospectively evaluate the safety (specifically severe radiation pneumonitis) and efficacy (overall survival, local control rate) of carbon-ion re-irradiation for recurrent or secondary lung cancer after initial radiotherapy using a multicenter registry, thereby clarifying appropriate indications. Basic objectives2 - Safety,Efficacy

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - 1. Patients in the J-CROS database who have a history of X-ray or particle beam therapy for primary lung cancer. 2. Patients who underwent carbon-ion therapy between January 2016 and June 2023. 3. Cases in which carbon-ion re-irradiation (including Re-irradiation Type 1, Type 2, and Repeat Organ Irradiation) was performed for lung cancer (primary tumor enlargement, intra-lung metastasis, or regional lymph node metastasis) or synchronous or metachronous multiple lung cancers. Key exclusion criteria - 1. Cases involving only a history of radiation therapy for other cancers (such as breast cancer or esophageal cancer). 2. Cases in which particle beam therapy was administered for another cancer following particle beam therapy for lung cancer. Target Size - 100

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 07 Month 15 Day Date of IRB - 2026 Year 08 Month 06 Day Anticipated trial start date - 2026 Year 11 Month 01 Day Last follow-up date - 2029 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000072044

Disclaimer: Curated by HT Syndication.