Tokyo, July 9 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058405) titled 'A Study on the Effects of Medicinal Mouthwash Use on Oral Bacterial Species in Patients with Chronic Glomerulonephritis' on July 9.

Study Type: Interventional

Study Design: Basic Design - Single arm Randomization - Non-randomized Blinding - Open -no one is blinded Control - Self control

Primary Sponsor: Institute - The University of Osaka

Condition: Condition - IgA nephropathy, Membranous nephropathy, Lupus nephritis, Focal segmental glomerulosclerosis (FSGS) Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - This study aims to investigate whether the use of ConCool F, a medicated mouthwash, by patients with chronic kidney disease (CKD) not only reduces oral bacteria but also has the potential to decrease proteinuria. Basic objectives2 - Safety,Efficacy

Intervention: Interventions/Control_1 - Gurgling with mouthwash for 1 years

Eligibility: Age-lower limit - Not applicable Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Patients receiving care at the Department of Nephrology, Seirei Hamamatsu Hospital, or Department of General Internal Medicine, Hyogo Medical University. Men and women aged 20 years or older who have been diagnosed with IgA nephropathy, membranous nephropathy, lupus nephritis, or focal segmental glomerulosclerosis, and who have proteinuria of 0.3 g/gCr or more on two consecutive occasions and an estimated glomerular filtration rate (eGFR) of 25 mL/min/1.73 m2 or more. Key exclusion criteria - Patients with IgA vasculitis will be excluded. Patients with suspected secondary IgA nephropathy, such as those with rheumatoid arthritis or Crohn's disease, will also be excluded. Patients with HbA1c 6.5% or more or those receiving antidiabetic medications other than SGLT2 inhibitors will be excluded. If the dosage of steroids or immunosuppressive drugs is increased during the period, the patient will be excluded from the study. Target Size - 80

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 01 Month 30 Day Date of IRB - 2025 Year 03 Month 31 Day Anticipated trial start date - 2025 Year 04 Month 08 Day Last follow-up date - 2027 Year 04 Month 08 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066772

Disclaimer: Curated by HT Syndication.