Tokyo, July 11 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058423) titled 'A study to investigate the actual status of multiplex genetic testing for non-small cell lung cancer. TORG2543' on July 10.

Study Type: Observational

Primary Sponsor: Institute - National Hospital Organization Hokkaido Cancer Center

Condition: Condition - non-small cell lung cancer Classification by malignancy - Malignancy Genomic information - YES

Objective: Narrative objectives1 - To investigate the real-world status of multiplex genetic testing in patients with advanced or recurrent non-small cell lung cancer. This includes collecting data on the frequency of positive gene mutations/translocations, the clinical backgrounds of mutation-positive patients, the use and effectiveness of various targeted therapies, and treatment outcomes. Additionally, we aim to compare the positivity rates across different multiplex assays and assess the frequency of newly detected actionable mutations/translocations by CGP (cancer genome profiling) testing in patients who had previously undergone multiplex testing at the start of treatment. Basic objectives2 - Safety,Efficacy

Eligibility: Age-lower limit - 20 years-old = 20 years at the time when the results of insurance-covered multiplex genetic testing became available. 4. Patients must have undergone one of the specified multiplex gene tests under insurance coverage before the initiation of first-line therapy for advanced or recurrent disease between January 1, 2021 and December 31, 2024. Patients receiving best supportive care or those who have not yet started treatment at the time of enrollment are also eligible. - Oncomine Dx Target Test Multi-CDx System (ODxTT) - AmoyDx Lung Cancer Multi-Gene PCR Panel (Amoy) - Lung Cancer Compact Panel Dx Multi-Companion Diagnostic System (CP) 5. Patient information can be collected from medical records. Key exclusion criteria - Patients who refused to participate in this study by opting out Target Size - 5000

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 05 Month 20 Day Date of IRB - 2025 Year 06 Month 30 Day Anticipated trial start date - 2025 Year 07 Month 10 Day Last follow-up date - 2025 Year 12 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066442

Disclaimer: Curated by HT Syndication.