Tokyo, April 18 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061303) titled 'Effects of knee extension training using a plate-loaded or weight-stack machine on quadriceps muscle hypertrophy' on April 18.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Open -but assessor(s) are blinded Control - Active

Primary Sponsor: Institute - Ritsumeikan University

Condition: Condition - Healthy young individual Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - This study aims to compare the effects of knee extension training using plate-loaded and weight-stack machines on quadriceps muscle hypertrophy. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Participants will perform knee extension training twice weekly for 12 weeks. One leg will be trained using a plate-loaded machine, whereas the contralateral leg will be trained using a weight-stack machine. Each training session will be performed with a prescribed number of repetitions and sets for each leg. Interventions/Control_2 - Participants will perform knee extension training twice weekly for 12 weeks. One leg will be trained using a plate-loaded machine, whereas the contralateral leg will be trained using a weight-stack machine. Each training session will be performed with a prescribed number of repetitions and sets for each leg.

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - Healthy young adults Key exclusion criteria - 1. Individuals who have performed exercises targeting the quadriceps femoris (e.g., knee extension exercises or squats) at least twice per week for 12 weeks or more within the past year, or who are currently engaged in such training. 2. Individuals with conditions that may interfere with study participation, including hepatic, renal, or cardiovascular diseases; respiratory disorders; endocrine or metabolic disorders; neurological disorders; disturbances of consciousness; vestibular dysfunction; sleep disorders; cardiovascular and circulatory diseases; diabetes mellitus (as defined by the criteria of the Japan Diabetes Society); or other conditions such as peripheral vascular reflex disorders, acute inflammation, skin diseases, or malignant tumors. 3. Individuals who have reported minor injuries within the past 4 weeks or severe musculoskeletal injuries within the past 6 months. 4. Individuals who are unable or unwilling to provide informed consent. 5. Individuals presenting with severe physical or mental conditions at the time of participation. 6. Individuals with a history of claustrophobia or panic disorder. 7. Individuals who are unable to remain at rest. 8. Individuals who are pregnant. 9. Individuals with a history of epileptic seizures. 10. Individuals with implanted medical devices such as cardiac pacemakers, defibrillators, or artificial heart valves. 11. Individuals with metal in their body (e.g., dental orthodontic bridges, crowns depending on material, clips, etc.). 12. Individuals with tattoos (as tattoo ink may react to magnetic fields). Target Size - 20

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 11 Month 04 Day Date of IRB - 2026 Year 01 Month 28 Day Anticipated trial start date - 2026 Year 04 Month 01 Day Last follow-up date - 2028 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070144

Disclaimer: Curated by HT Syndication.