Tokyo, April 30 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061407) titled 'Study on Mood and Psychological Stress After a Single Intake of Dashi' on April 30.

Study Type: Interventional

Study Design: Basic Design - Cross-over Randomization - Randomized Blinding - Single blind -participants are blinded Control - Placebo

Primary Sponsor: Institute - Toyo University

Condition: Condition - None (Healthy adults) Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To evaluate the effects of a single intake of dashi on psychological stress indicators and subjective calmness. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - After completion of a mild mental stress task, participants consume 100 mL of dashi at 60 degrees Celsius as a single oral intake, and outcome measures are assessed repeatedly before and after intake. Each condition is conducted on separate days with a washout period of at least 7 days. Interventions/Control_2 - After completion of a mild mental stress task, participants consume 100 mL of a salt-control sample at 60 degrees Celsius as a single oral intake, with the sodium chloride concentration matched to that of the dashi condition. Outcome measures are assessed repeatedly before and after intake. Each condition is conducted on separate days with a washout period of at least 7 days.

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - - Healthy adults (male and female) aged 18 to 45 years. - Individuals who have received a full explanation of the study objectives and procedures and have provided written informed consent. - Individuals in good physical condition on the day of measurement and able to complete the study procedures without difficulty. - Individuals who are able to normally consume dashi ingredients (seafood, kelp, and mushrooms). Key exclusion criteria - - Individuals with a history of or currently receiving treatment for cardiovascular, metabolic, neurological, or endocrine disorders. - Individuals who regularly use medications that may affect autonomic nervous system function (e.g., antihypertensive agents, anxiolytics, hypnotics/sleeping medications). - Current smokers or individuals with a habitual pattern of excessive alcohol consumption. - Individuals with taste or olfactory disorders, or with food allergies to seafood, kelp, umami seasonings, or related ingredients. - Individuals who are pregnant or breastfeeding. - Individuals reporting significant physical discomfort or poor health condition on the day of the study. - Individuals judged by the principal investigator to be unsuitable for participation in the study. Target Size - 35

Recruitment Status: Recruitment status - Enrolling by invitation Date of protocol fixation - 2026 Year 03 Month 21 Day Date of IRB - 2026 Year 03 Month 21 Day Anticipated trial start date - 2026 Year 04 Month 23 Day Last follow-up date - 2027 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070261

Disclaimer: Curated by HT Syndication.