Tokyo, Sept. 25 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059177) titled 'Exploratory study on lung perfusion measurement using electrical impedance tomography' on Sept. 25.

Study Type: Interventional

Study Design: Basic Design - Single arm Randomization - Non-randomized Blinding - Open -no one is blinded Control - Uncontrolled

Primary Sponsor: Institute - Shimane university

Condition: Condition - acute respiratory failure with PaO2/FIO2 less than 300 mmHg and mechanically ventilated Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - When monitoring pulmonary blood flow using electrical impedance tomography (EIT), ventilation is typically paused to avoid measurement interference from ventilation. However, the extent to which measurement results are affected when measurements are taken without pausing ventilation has not been investigated. This study investigates the difference in pulmonary blood flow measurements between these two methods in the same hypoxemic mechanically ventilated patients, exploring the necessity of ventilation cessation during measurement. Basic objectives2 - Others

Intervention: Interventions/Control_1 - Intervention to measure pulmonary blood flow without discontinuing mechanical ventilation

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1) The patient exhibits hypoxemia (PaO2/FIO2 below 300 mmHg) and is receiving mechanical ventilation. 2) A central venous line is inserted via the internal jugular vein. 3) The patient is 18 years of age or older at the time of enrollment. 4) Written informed consent for study participation has been obtained from the patient or a legally authorized representative. Key exclusion criteria - 1) Hypotension or heart failure requiring high-dose catecholamine administration. 2) Renal failure requiring dialysis. 3) Hypernatremia (latest sodium value within 1 day prior to registration more than 145 mEq/L). 4) Thoracic deformity observed on chest CT or chest X-ray. 5) Pacemaker implantation. Target Size - 40

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 09 Month 24 Day Anticipated trial start date - 2025 Year 10 Month 01 Day Last follow-up date - 2028 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067684

Disclaimer: Curated by HT Syndication.