Tokyo, April 30 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060567) titled 'Heterogeneous Treatment Effects of Early High-Dose Rehabilitation in Acute Ischemic Stroke: Target Trial Emulation and Causal Forests' on April 30.
Study Type:
Observational
Primary Sponsor:
Institute - Mie University
Condition:
Condition - Ischemic Stroke
Classification by malignancy - Others
Genomic information - NO
Objective:
Narrative objectives1 - This study aims to operationally define and evaluate an "early high-dose" regimen (initiated = 18 years; (3) pre-admission modified Rankin Scale (mRS) score <= 4; and (4) confirmed stay in a stroke care unit (SCU) on the day of admission (Day 1-SCU). Time zero was defined as the admission date (Day 1). Day 1-SCU was identified using a claims-based proxy definition: the first billing date of an SCU-related management fee in the DPC data coinciding with the admission date.
Key exclusion criteria - Exclusion criteria were: (1) cases suggestive of in-hospital onset; (2) cases with clear evidence of long-term care (LTC) residence prior to admission; and (3) cases with an explicit contraindication to rehabilitation immediately after admission (e.g., immediately after decompressive craniectomy, ventricular drainage/external ventricular drain [EVD] placement, initiation of extracorporeal membrane oxygenation [ECMO], or initiation of high-dose vasopressors).
Target Size - 40000
Recruitment Status:
Recruitment status - Preinitiation
Date of protocol fixation - 2026 Year 02 Month 21 Day
Anticipated trial start date - 2026 Year 02 Month 22 Day
Last follow-up date - 2026 Year 03 Month 31 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068230
Disclaimer: Curated by HT Syndication.
