Tokyo, Aug. 24 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062033) titled 'Meteorological and Environmental Factors Associated with the Onset of Subarachnoid Hemorrhage' on Aug. 24.

Study Type: Observational

Primary Sponsor: Institute - Tokushima University

Condition: Condition - subarachnoid hemorrhage Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - The objective of this study is to elucidate, through a case-crossover design, the causal relationship and lag effects between rapid decreases in apparent temperature, exposure to ambient air pollutants (PM2.5, NO2, and Ox), and the onset of spontaneous subarachnoid hemorrhage (SAH) in patients admitted to Tokushima University Hospital. In addition, we aim to determine whether susceptibility to meteorological and air environmental fluctuations differs according to aneurysm characteristics, including size, location, morphology (presence of blebs), and UCAS Japan risk stratification score, through interaction analyses. The ultimate goal is to provide evidence supporting the development of personalized preventive medicine for individuals at high risk of aneurysm rupture. Basic objectives2 - Others

Eligibility: Age-lower limit - Not applicable Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - This study will include patients with spontaneous subarachnoid hemorrhage (SAH) registered in the Tokushima University Hospital SCU database who were emergently transported to and admitted to the hospital between January 1, 2020, and September 30, 2025 (target sample size: 200). Cases with clearly identifiable onset date and time and residential address or location of onset in the medical records will be included. Key exclusion criteria - 1. Patients with traumatic subarachnoid hemorrhage (SAH).

2. Patients for whom the date and time of onset and/or residential location information are unavailable, making linkage with meteorological and environmental data impossible.

3. Patients for whom an explicit refusal to participate was expressed by the patient or their legally authorized representative through the opt-out process (e.g., information disclosure document) regarding the use of their information in this study. Target Size - 200

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 08 Month 24 Day Date of IRB - 2026 Year 08 Month 24 Day Anticipated trial start date - 2026 Year 08 Month 24 Day Last follow-up date - 2028 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070978

Disclaimer: Curated by HT Syndication.