Tokyo, March 16 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060923) titled 'Investigation of the effects of thermal stimulation on cognitive task load and brain activity' on March 16.

Study Type: Interventional

Study Design: Basic Design - Cross-over Randomization - Randomized Blinding - Open -no one is blinded Control - No treatment

Primary Sponsor: Institute - Kao Corporation

Condition: Condition - Not applicable Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To evaluate fatigue-related changes in brain networks and to examine, within the same participants, the extent to which thermal stimulation affects the fatigue-associated decreases. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Thermal stimulation will be applied during a 60-minute cognitive task session -> 2-week washout -> 60-minute cognitive task session without intervention Interventions/Control_2 - 60-minute cognitive task session without intervention -> 2-week washout ->Thermal stimulation will be applied during a 60-minute cognitive task session

Eligibility: Age-lower limit - 20 years-old = Gender - Male Key inclusion criteria - 1. Males aged 20-59 who are right-handed. 2. Full-time (regular) employees working at Kao Corporation's Odawara and Sumida sites. 3. Individuals who can understand and respond to questionnaires written in Japanese. Key exclusion criteria - 1. Individuals who do not meet the requirements for undergoing MRI measurements. 2. Individuals who are sensitive to cold. 3. Individuals who are uncomfortable with cold stimuli. 4. Individuals who find it difficult to use, or are uncomfortable using, medicated patches (topical compress/patch preparations). 5. Individuals who dislike the scent of bergamot or mint. 6. Individuals who have a strong reaction to alcohol swabs (alcohol-impregnated cotton). 7. Individuals whom the principal investigator deems unsuitable for participation for any other reason, such as noncompliance with study obligations. Target Size - 20

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 03 Month 11 Day Date of IRB - 2026 Year 03 Month 11 Day Anticipated trial start date - 2026 Year 03 Month 16 Day Last follow-up date - 2026 Year 04 Month 24 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069722

Disclaimer: Curated by HT Syndication.