Tokyo, March 3 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060793) titled 'Multicenter Collaborative Study on Biomarker Analysis Using Circulating Tumor DNA in Resectable Solid Tumors' on March 2.

Study Type: Observational

Primary Sponsor: Institute - National Cancer Center Hospital East

Condition: Condition - Clinical stage I-IV resectable solid tumors planned to be treated with definitive therapy Classification by malignancy - Malignancy Genomic information - YES

Objective: Narrative objectives1 - This study aims to identify biomarkers reflecting the molecular biological nature of resectable solid tumors by performing comprehensive molecular profiling of blood and tumor tissue specimens from patients undergoing curative-intent treatment, and integrating these data with clinical information. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Patients who meet all eligibility criteria and none of the exclusion criteria will be enrolled in this study. 1)18 years-old <= 2)Diagnosed with a resectable solid tumor of clinical stage I-IV. 3)Planned to undergo curative-intent treatment, including curative surgical resection or definitive chemotherapy/chemoradiotherapy.*1 4)Availability of tumor tissue specimens for pathological evaluation.*2 5)ECOG Performance Status (PS) of 0 or 1. 6)Written informed consent. *1 Patients scheduled for curative resection are eligible even if they undergo preoperative chemoradiotherapy. *2 A tissue biopsy prior to treatment initiation is preferred; however, surgical specimens are acceptable in cases undergoing surgery. Key exclusion criteria - 1)Active multiple primary cancers 2)Pregnant 3)History of other malignancies within 3 years prior to enrollment 4)Severe comorbid diseases (e.g., poorly controlled diabetes, infections, symptomatic interstitial pneumonia or pulmonary fibrosis) 5)Other reasons deemed inappropriate for this study by the principal investigator. Target Size - 4000

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 02 Month 19 Day Date of IRB - 2026 Year 02 Month 24 Day Anticipated trial start date - 2026 Year 04 Month 01 Day Last follow-up date - 2034 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068986

Disclaimer: Curated by HT Syndication.