Tokyo, Sept. 10 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062849) titled 'A Study on the Effects of Aging and Exercise on Cardiovascular, Cognitive, and Motor Functions' on Sept. 10.
Study Type:
Interventional
Study Design:
Basic Design - Parallel
Randomization - Randomized
Blinding - Open -no one is blinded
Control - Placebo
Primary Sponsor:
Institute - National Institute of Advanced Industrial Science and Technology
Condition:
Condition - Adult
Classification by malignancy - Others
Genomic information - NO
Objective:
Narrative objectives1 - This study aims to characterize age-related declines in cardiovascular regulatory function and to explore strategies for preventing cardiovascular disease and dementia. In healthy adults, arterial morphology and hemodynamic responses (blood pressure and blood flow) in the heart, brain, and skeletal muscle will be assessed during physiological perturbations to evaluate vascular function. Comparisons across age groups and habitual exercise status will determine whether regular physical activity attenuates these declines. In addition, an interventional study will examine the effects of structured exercise programs (stretching, aerobic, resistance, and combined training) on cardiovascular regulation. Cognitive function, physical performance, and mood will also be assessed to examine their relationships with cardiovascular regulatory function.
Basic objectives2 - Efficacy
Intervention:
Interventions/Control_1 - stretching and balance exercise training
Interventions/Control_2 - aerobic exercise training
Eligibility:
Age-lower limit - 18
years-old
Gender - Male and Female
Key inclusion criteria - Individuals who are able to provide written informed consent voluntarily
Individuals aged 18 to <90 years at the time of consent
Men and women
Individuals who are physically able to exercise or walk continuously for 30 minutes
For participation in the exercise training intervention, individuals aged <75 years at baseline
For MRI assessments, individuals aged <85 years
Key exclusion criteria - History of neurological disease, heart disease, or stroke. Presence of psychiatric disease. Exercise limitation due to disease. Systolic blood pressure higher than 180 mmHg or diastolic blood pressure higher than 110 mmHg. Habitual smoking within the past year. Pregnancy or possible pregnancy, Implanted pacemaker
Target Size - 300
Recruitment Status:
Recruitment status - Preinitiation
Date of protocol fixation - 2026 Year 06 Month 13 Day
Date of IRB - 2026 Year 08 Month 01 Day
Anticipated trial start date - 2026 Year 10 Month 01 Day
Last follow-up date - 2028 Year 03 Month 31 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070256
Disclaimer: Curated by HT Syndication.
