Tokyo, July 25 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062313) titled 'Study on the Effects of Listening to 40Hz Amplitude-Modulated Sounds on Gamma-Band Brain Wave' on July 24.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Double blind -all involved are blinded Control - Placebo

Primary Sponsor: Institute - National Institute of Advanced Industrial Science and Technology (AIST)

Condition: Condition - Healthy adults Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To elucidate the effects of long-term listening to 40 Hz modulated sounds on gamma-band EEG activity in healthy older adults. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Listening to music stimuli subjected to 40 Hz amplitude modulation (1 hour daily for a total of 180 days). Interventions/Control_2 - Listening to music stimuli subjected to noise-addition processing (1 hour daily for a total of 180 days).

Eligibility: Age-lower limit - 65 years-old

Gender - Male and Female Key inclusion criteria - (1) Individuals capable of providing written informed consent to participate in the study of their own free will (2) Individuals aged 65 to 74 years at the time of obtaining consent (3) Gender: No restriction Key exclusion criteria - (1) Individuals with hearing impairment (2) Individuals with depression or anxiety disorders (diagnosed with depression/anxiety disorders or currently taking antidepressants/anxiolytics) or those with a GDS-15 score of 5 or higher (3) Individuals with dementia (diagnosed with dementia or currently taking dementia medication) or those with an MMSE score of 27 or lower (4) Individuals diagnosed with epilepsy or currently taking medication for epilepsy (5) Individuals who self-report having a mental disorder such as schizophrenia spectrum disorder or bipolar disorder (6) Individuals who self-report having a developmental disorder such as autism spectrum disorder or attention-deficit/hyperactivity disorder (ADHD) (7) Individuals unable to properly undergo EEG measurement and psychological testing (8) Individuals with a history of routine use of commercially available products that play 40 Hz modulated sounds (9) Any other individuals deemed unsuitable by the principal investigator or co-investigators Target Size - 40

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 07 Month 13 Day Date of IRB - 2026 Year 07 Month 16 Day Anticipated trial start date - 2026 Year 07 Month 24 Day Last follow-up date - 2027 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000071309

Disclaimer: Curated by HT Syndication.