Tokyo, Sept. 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058638) titled 'The association between salivary amylase and blood glucose level after starch loading' on Sept. 1.

Study Type: Interventional

Study Design: Basic Design - Single arm Randomization - Non-randomized Blinding - Open -no one is blinded Control - Uncontrolled

Primary Sponsor: Institute - Japan Women's University

Condition: Condition - Glucose metabolism disorder, Diabetes Classification by malignancy - Others Genomic information - YES

Objective: Narrative objectives1 - The purpose is to investigate the association between salivary amylase gene (AMY1) copy number variation and salivary amylase activity and glucose and lipid metabolism after starch loading. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - 150 g of cooked rice is immediately ingested. Subsequently, blood glucose, HbA1c, insulin, glucagon, incretin (GLP-1, GIP), triglyceride and lipase, salivary amylase activity, serum amylase isoenzymes are measured before and after the rice loading. Additionally, salivary amylase gene (AMY1) copy number variation are assessed.

Eligibility: Age-lower limit - 20 years-old = Gender - Female Key inclusion criteria - Participants will be enrolled in the Japan Women's University during the study period and will fulfill both criteria 1) and 2). 1) Those who fulfill all the following conditions. 1. Women aged 20-29 years old 2. BMI less than 30kg/m2 3. No impaired glucose tolerance in the past year 4. No special eating habits (unbalanced vegetarianism, etc.) or excessive exercise habits 5. No smoking habits or excessive drinking habits 6. Those who were determined to be eligible for continuous blood sampling via antecubital vein using an indwelling needle, based on the results of a medical interview conducted by the principal investigator. 7. Those who have not been diagnosed with anemia in the past year 8. Those who are not allergic to heparin. 9. Those who do not have any diseases or are not taking any medications that may cause thrombosis. 10. Able to consume cooked rice 11. Able to self-measure blood glucose and undergo saliva sampling 12. Not taking medications for Sjogren's syndrome or that affect salivation 13. No problem with being asked about their blood type 2) Those who can understand the contents of this study after receiving an explanation of the study and have given their consent to participate in the study. Key exclusion criteria - Those who do not fulfill the inclusion criteria 1)1-11 or 2) will be excluded. Additionally, those who are inappropriate by the study director and researchers will also be excluded (such as those with moderate to severe underlying diseases). Target Size - 45

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 12 Month 31 Day Anticipated trial start date - 2026 Year 02 Month 01 Day Last follow-up date - 2026 Year 09 Month 30 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067055

Disclaimer: Curated by HT Syndication.