Tokyo, March 6 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060836) titled 'Biomarker Study with FDG-PET/CT Analysis in Induction Chemo-radiation Therapy Followed by Surgery with Perioperative Immunotherapy for Resectable Stage Discreate N2 IIIA-B Non-small Cell Lung Cancer (SQUAT-TR2 Study) ( WJOG12119LTR2)' on March 5.

Study Type: Observational

Primary Sponsor: Institute - West Japan Oncology Group

Condition: Condition - Non-small cell lung cancer Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - This study aims to explore the clinical significance of FDG-PET/CT derived parameters as biomarkers for predicting preoperative pathological response and recurrence in patients enrolled in the Phase 2 trial entitled "A Phase 2 Study of Quadruple-Modality Therapy Incorporating Induction Chemoradiotherapy Plus Perioperative Immunotherapy for Resectable Discrete N2 Stage 3A-B Non-Small Cell Lung Cancer" (WJOG12119L). FDG-PET/CT imaging data obtained as part of the WJOG12119L trial will be analyzed to evaluate their potential utility as predictive biomarkers of pathological response prior to surgery to the study treatment regimen, which consists of induction chemoradiotherapy combined with preoperative and postoperative immunotherapy. Basic objectives2 - Others

Eligibility: Age-lower limit - Not applicable Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Patients who were enrolled in WJOG12119L and, at the time of enrollment in the present study, had not withdrawn their informed consent for that trial. Key exclusion criteria - Patients deemed inappropriate for inclusion by the attending physician. Target Size - 30

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 02 Month 28 Day Anticipated trial start date - 2026 Year 04 Month 20 Day Last follow-up date - 2028 Year 04 Month 19 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069587

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