Japan, Sept. 16 -- RP SCHERER TECHNOLOGIES LLC has got intellectual property rights for 'FORMULATION FOR ORAL DELIVERY OF PROTEINS, PEPTIDES AND SMALL MOLECULES WITH POOR PERMEABILITY.' Other related details are as follows:
Application Number: JP,2025-006997
Category (FI): A61K47/10,A61K9/107,A61K38/03,A61K45/00,A61K38/08,A61K38/10,A61K47/14
Stage: PROBLEM TO BE SOLVED: To provide formulations for orally administered poorly permeable molecules, which is highly beneficial for patients who require multiple daily doses, by overcoming at least this low permeability to the intestinal membrane and overcoming, for some of these molecules, particularly peptides and proteins, the chemical and physical instability in the gastrointestinal tract, specifically the loss of activity due to the acidic conditions in the stomach, and the enzymatic degradation throughout the intestine.SOLUTION: Applicants have developed a pharmaceutical formulation intended for oral delivery of a synthetic or natural poorly permeable molecule or a salt/solvate thereof having a therapeutic activity. The pharmaceutical formulation can include a synthetic or natural poorly permeable molecule or a salt or solvate thereof in an amount of 0.01 to 10 wt.% of the total weight of the formulation; a lipophilic phase comprising a triglyceride of a fatty acid in an amount of 50 to 80 wt.% of the total weight of the formulation; and at least one lipophilic surfactant comprising a partial ester of a polyol and a fatty acid in an amount of about 10 to 50 wt.% of the total weight of the formulation.SELECTED DRAWING: None (Grant)
Filing Date: Jan. 17, 2025
Publication Date: April 10, 2025
The original document can be viewed at: https://www.j-platpat.inpit.go.jp/p0100
Disclaimer: Curated by HT Syndication.
