Japan, Sept. 16 -- KUROS US LLC has got intellectual property rights for 'GUANINE-RICH OLIGONUCLEOTIDES.' Other related details are as follows:
Application Number: JP,2023-185076
Category (FI): C07H21/00,C12N15/11@Z,C07H21/04@A
Stage: PROBLEM TO BE SOLVED: To provide methods for oligonucleotide synthesis, specifically the synthesis of oligonucleotides that contain a high content of guanine monomers.SOLUTION: A method for coupling a nucleoside phosphoramidite during the synthesis of an oligonucleotide to a universal support, to a first nucleoside, or to an extending oligonucleotide, wherein the oligonucleotide comprises a region of 3 or more consecutive guanine monomers, and wherein the method comprising the steps of: (i) generating a coupling solution, wherein the coupling solution comprises: (a) the nucleoside phosphoramidite; (b) an activating reagent; and (c) one or more solvents, wherein one of the one or more solvents is N,N-dimethylformamide (DMF); and (ii) contacting the coupling solution with the universal support, with the first nucleoside, or with the extending oligonucleotide.SELECTED DRAWING: None (Grant)
Filing Date: Oct. 27, 2023
Publication Date: Feb. 21, 2024
The original document can be viewed at: https://www.j-platpat.inpit.go.jp/p0100
Disclaimer: Curated by HT Syndication.
