Japan, Feb. 27 -- JAPAN FINECHEM CO INC has got intellectual property rights for 'PRODUCTION METHOD OF CYCLIZATION PRODUCT FORMED BY CYCLIZATION REACTION INVOLVING DEHYDRATION CONDENSATION, AND PRODUCTION METHOD OF 1,3,4-SUBSTITUTED PYRAZOLE-5-CARBOXYLIC ACID ESTER.' Other related details are as follows:
Application Number: JP,2022-013347
Category (FI): A61K31/415,C07D231/14
Stage: PROBLEM TO BE SOLVED: To provide a production method of a cyclization product in a cyclization reaction involving dehydration condensation in which no removal step of by-product water, such as an azeotropic dehydration operation or addition of an inorganic solid dehydrator requiring a filtration step after the reaction, is needed, and as an invention of the embodiment, to provide a simple and advantageous production method at an industrial scale in producing 1,3,4-substituted pyrazole-5-carboxylic acid esters useful as important intermediates in medical and agrochemical field and the like.SOLUTION: Invented is a reaction method which uses carbonic acid esters as a dehydrator in a cyclization reaction involving dehydration condensation. More concretely, invented is a production method at an industrial scale of 1,3,4-substituted pyrazole-5-carboxylic acid esters which uses carbonic acid esters as a dehydrator in a cyclization reaction of a hydrazino acetic acid ester derivative.SELECTED DRAWING: None (Grant)
Filing Date: Jan. 31, 2022
Publication Date: Aug. 10, 2023
The original document can be viewed at: https://www.j-platpat.inpit.go.jp/p0100
Disclaimer: Curated by HT Syndication.
