Japan, Sept. 16 -- UNIV DUKE has got intellectual property rights for 'RNA-GUIDED GENE EDITING AND GENE REGULATION.' Other related details are as follows:
Application Number: JP,2023-131956
Category (FI): C12N15/86@Z,C12N1/21,C12N1/15,C12N15/62@Z,C07K14/78,C12N5/10,C07K14/47,C12N9/16@Z,C12N15/09,100,C12N15/55,C12N15/864,100@Z,C12N1/19,C12N15/861@Z,C12N15/63@Z,C12N15/09,110,A61K35/76,A61K48/00,A61K31/7088,A61K38/02,A61P21/02
Stage: PROBLEM TO BE SOLVED: To provide Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions, and methods of using the CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering, and also to provide compositions and methods of using the compositions for altering gene expression and genome engineering in muscle such as skeletal muscle and cardiac muscle.SOLUTION: The present invention is directed to a fusion protein comprising two heterologous polypeptide domains. The first polypeptide domain comprises a clustered regularly interspaced short palindromic repeats associated (Cas) protein, and the second polypeptide domain has an activity selected from the group consisting of transcription activation activity, transcription repression activity, transcription release factor activity, histone modification activity, nuclease activity, nucleic acid association activity, methylase activity, and demethylase activity.SELECTED DRAWING: Figure 1 (Grant)
Filing Date: Aug. 14, 2023
Publication Date: Nov. 14, 2023
The original document can be viewed at: https://www.j-platpat.inpit.go.jp/p0100
Disclaimer: Curated by HT Syndication.
